Can Markov Chain Models Predict Nucleosome Positioning?
نویسندگان
چکیده
منابع مشابه
Can Markov Chain Models Mimic Biological Regulation?
A fundamental question in biology is whether the network of interactions that regulate gene expression can be modeled by existing mathematical techniques. Studies of the ability to predict a gene’s state based on the states of other genes suggest that it may be possible to abstract sufficient information to build models of the system that retain steady-state behavioral characteristics of the re...
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Nucleosome positioning is not only related to genomic DNA compaction but also to other biological functions. After the chromatin is digested by micrococcal nuclease, nucleosomal (nucleosome-bound) DNA fragments can be sequenced and mapped on the genomic DNA sequence. Due to the development of modern DNA sequencing technology, genome-wide nucleosome mapping has been performed in a wide range of ...
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Nucleosome positioning has been the subject of intense study for many years. The properties of micrococcal nuclease, the enzyme central to these studies, are discussed. The various methods used to determine nucleosome positions in vitro and in vivo are reviewed critically. These include the traditional low resolution method of indirect end-labelling, high resolution methods such as primer exten...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.2179